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TRIM39
E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Belongs to the TRIM/RBCC family. Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 6p22.1 |
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Cellular Component:
cytoplasm; cytosol; mitochondrion; nucleus
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Molecular Function:
identical protein binding; protein binding; ubiquitin protein ligase activity; zinc ion binding
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Biological Process:
apoptotic process; mitotic G2 DNA damage checkpoint signaling; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-dependent protein catabolic process; positive regulation of apoptotic signaling pathway; protein stabilization; protein ubiquitination; regulation of cell cycle G1/S phase transition
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Reference #:
Q9HCM9
(UniProtKB)
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Alt. Names/Synonyms: E3 ubiquitin-protein ligase TRIM39; MGC32984; RING finger protein 23; RING-type E3 ubiquitin transferase TRIM39; RNF23; Testis-abundant finger protein; TFP; TRI39; TRIM39; TRIM39B; tripartite motif containing 39; tripartite motif-containing 39; Tripartite motif-containing protein 39
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Gene Symbols: TRIM39
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Molecular weight:
59,690 Da
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Basal Isoelectric point:
7.8
Predict pI for various phosphorylation states
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