TIA1 Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component:  cytoplasm; cytoplasmic stress granule; cytosol; nuclear stress granule; nucleoplasm
Molecular Function:  mRNA 3'-UTR AU-rich region binding; poly(A) binding; protein binding
Biological Process:  apoptotic process; fibroblast growth factor receptor signaling pathway; negative regulation of cytokine biosynthetic process; negative regulation of translation; positive regulation of epithelial cell apoptotic process; protein localization to cytoplasmic stress granule; regulation of mRNA splicing, via spliceosome
Disease: Amyotrophic Lateral Sclerosis 26 With Or Without Frontotemporal Dementia; Welander Distal Myopathy
Reference #:  P31483 (UniProtKB)
Alt. Names/Synonyms: cytotoxic granule-associated RNA-binding protein; nucleolysin TIA-1; Nucleolysin TIA-1 isoform p15; Nucleolysin TIA-1 isoform p40; p15-TIA-1; p40-TIA-1; p40-TIA-1 (containing p15-TIA-1); RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA-1; TIA1; TIA1 cytotoxic granule associated RNA binding protein; TIA1 cytotoxic granule-associated RNA binding protein; TIA1 cytotoxic granule-associated RNA-binding protein; WDM
Gene Symbols: TIA1
Molecular weight: 42,963 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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