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NCOA5
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). Widely expressed. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 20q13.12 |
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Cellular Component:
actin cytoskeleton; nucleus
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Molecular Function:
chromatin binding; protein binding
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Biological Process:
glucose homeostasis; negative regulation of insulin receptor signaling pathway
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Reference #:
Q9HCD5
(UniProtKB)
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Alt. Names/Synonyms: bA465L10.6; CIA; Coactivator independent of AF-2; KIAA1637; NCoA-5; NCOA5; Nuclear receptor coactivator 5
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Gene Symbols: NCOA5
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Molecular weight:
65,536 Da
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Basal Isoelectric point:
9.62
Predict pI for various phosphorylation states
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