NCOA5 Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 20q13.12
Cellular Component:  actin cytoskeleton; nucleus
Molecular Function:  chromatin binding; protein binding
Biological Process:  glucose homeostasis; negative regulation of insulin receptor signaling pathway
Reference #:  Q9HCD5 (UniProtKB)
Alt. Names/Synonyms: bA465L10.6; CIA; Coactivator independent of AF-2; KIAA1637; NCoA-5; NCOA5; Nuclear receptor coactivator 5
Gene Symbols: NCOA5
Molecular weight: 65,536 Da
Basal Isoelectric point: 9.62  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA