SETD3 Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD3 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of human Ortholog: 14q32.2

Cellular Component: chromatin; cytoplasm; nucleoplasm

Molecular Function: actin binding; histone H3K36 methyltransferase activity; histone H3K4 methyltransferase activity; protein binding; protein-L-histidine N-tele-methyltransferase activity; protein-lysine N-methyltransferase activity; RNA polymerase II-specific DNA-binding transcription factor binding; transcription coactivator activity

Biological Process: actin modification; chromatin remodeling; peptidyl-histidine methylation; peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; peptidyl-lysine trimethylation; positive regulation of DNA-templated transcription; positive regulation of muscle cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of uterine smooth muscle contraction

Reference #: Q86TU7 (UniProtKB)

Alt. Names/Synonyms: Actin-histidine N-methyltransferase; C14orf154; DKFZp761E1415; FLJ23027; Histone-lysine N-methyltransferase setd3; hSETD3; MGC87236; SET domain containing 3; SET domain containing 3, actin histidine methyltransferase; SET domain-containing protein 3; SETD3

Gene Symbols: SETD3

Molecular weight: 67,257 Da

Basal Isoelectric point: 5.72 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

Select Structure to View Below
SETD3

Get PyMOL Script Get Chimera Script