TMTC4 Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Belongs to the TMTC family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q32.3
Cellular Component:  endoplasmic reticulum; integral component of membrane
Molecular Function:  dolichyl-phosphate-mannose-protein mannosyltransferase activity; mannosyltransferase activity
Biological Process:  protein O-linked mannosylation
Reference #:  Q5T4D3 (UniProtKB)
Alt. Names/Synonyms: FLJ14624; FLJ22153; TMTC4; transmembrane and tetratricopeptide repeat containing 4; Transmembrane and TPR repeat-containing protein 4
Gene Symbols: TMTC4
Molecular weight: 82,991 Da
Basal Isoelectric point: 9.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein