Fer Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed. 3 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Fer family; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of human Ortholog: 5q21.3
Cellular Component:  actin cytoskeleton; anchoring junction; cell cortex; cell junction; chromatin; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; lamellipodium; microtubule cytoskeleton; nucleus; type III intermediate filament
Molecular Function:  actin binding; ATP binding; cadherin binding; delta-catenin binding; epidermal growth factor receptor binding; gamma-catenin binding; lipid binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase 1 binding; protein tyrosine kinase activity; protein tyrosine kinase binding; signaling receptor binding; small GTPase binding
Biological Process:  actin cytoskeleton reorganization; adherens junction assembly; adherens junction disassembly; cell adhesion; cell differentiation; cell population proliferation; cell-cell adhesion mediated by cadherin; cellular response to insulin stimulus; cellular response to macrophage colony-stimulating factor stimulus; cellular response to reactive oxygen species; chemotaxis; cytokine-mediated signaling pathway; diapedesis; extracellular matrix-cell signaling; Fc-epsilon receptor signaling pathway; germ cell development; innate immune response; insulin receptor signaling pathway via phosphatidylinositol 3-kinase; interleukin-6-mediated signaling pathway; intracellular signal transduction; Kit signaling pathway; microtubule cytoskeleton organization; negative regulation of mast cell activation involved in immune response; peptidyl-tyrosine phosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of NF-kappaB transcription factor activity; protein autophosphorylation; protein phosphorylation; regulation of epidermal growth factor receptor signaling pathway; regulation of fibroblast migration; regulation of lamellipodium assembly; regulation of mast cell degranulation; regulation of protein phosphorylation; response to lipopolysaccharide; response to platelet-derived growth factor; Sertoli cell development; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase signaling pathway; tyrosine phosphorylation of STAT protein
Reference #:  P16591 (UniProtKB)
Alt. Names/Synonyms: Feline encephalitis virus-related kinase FER; FER; fer (fps/fes related) tyrosine kinase; FER tyrosine kinase; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; p94-Fer; phosphoprotein NCP94; PPP1R74; protein phosphatase 1, regulatory subunit 74; Proto-oncogene c-Fer; TYK3; Tyrosine kinase 3; Tyrosine-protein kinase Fer
Gene Symbols: FER
Molecular weight: 94,638 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene