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H3.X
Primate-specific variant histone H3, which constitutes a core component of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H3 family. Expressed at low level in some tissues, such as testis and brain. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 5p15.1 |
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Cellular Component:
nucleosome; nucleus
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Molecular Function:
DNA binding; protein heterodimerization activity; structural constituent of chromatin
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Reference #:
P0DPK5
(UniProtKB)
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Alt. Names/Synonyms: H3.X; H3.Y.2; H3X; H3Y2; histone H3.X; Histone H3.Y2
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Gene Symbols: H3Y2
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Molecular weight:
16,335 Da
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Basal Isoelectric point:
11.39
Predict pI for various phosphorylation states
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