H3.X Primate-specific variant histone H3, which constitutes a core component of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H3 family. Expressed at low level in some tissues, such as testis and brain. Note: This description may include information from UniProtKB.
Chromosomal Location of human Ortholog: 5p15.1
Cellular Component:  nucleosome; nucleus
Molecular Function:  DNA binding; protein heterodimerization activity; structural constituent of chromatin
Reference #:  P0DPK5 (UniProtKB)
Alt. Names/Synonyms: H3.X; H3.Y.2; H3X; H3Y2; histone H3.X; Histone H3.Y2
Gene Symbols: H3Y2
Molecular weight: 16,335 Da
Basal Isoelectric point: 11.39  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Protein Atlas  |  BioGPS  |  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein