5-HT(6) This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity. Is an activator of TOR signaling. Belongs to the G-protein coupled receptor 1 family. Expressed in several human brain regions, most prominently in the caudate nucleus. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 1p36.13
Cellular Component:  cilium; plasma membrane
Molecular Function:  histamine receptor activity; protein binding
Biological Process:  cerebral cortex cell migration; G protein-coupled receptor signaling pathway; G protein-coupled serotonin receptor signaling pathway; positive regulation of TOR signaling
Reference #:  P50406 (UniProtKB)
Alt. Names/Synonyms: 5-HT(6); 5-HT-6; 5-HT6; 5-HT6R; 5-hydroxytryptamine (serotonin) receptor 6; 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled; 5-hydroxytryptamine receptor 6; 5HT6R; HTR6; Serotonin receptor 6
Gene Symbols: HTR6
Molecular weight: 46,954 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene