SEC24B Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes. Belongs to the SEC23/SEC24 family. SEC24 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of human Ortholog: 4q25
Cellular Component:  COPII vesicle coat; cytosol; endoplasmic reticulum exit site; endoplasmic reticulum membrane; ER to Golgi transport vesicle membrane
Molecular Function:  protein binding; SNARE binding; zinc ion binding
Biological Process:  aorta morphogenesis; auditory receptor cell stereocilium organization; cochlear nucleus development; COPII-coated vesicle cargo loading; coronary artery morphogenesis; endoplasmic reticulum to Golgi vesicle-mediated transport; intracellular protein transport; lung lobe morphogenesis; neural tube closure; outflow tract morphogenesis; pulmonary artery morphogenesis; regulation of cargo loading into COPII-coated vesicle; regulation of establishment of planar polarity involved in neural tube closure
Reference #:  O95487 (UniProtKB)
Alt. Names/Synonyms: MGC48822; Protein transport protein Sec24B; SC24B; SEC24; SEC24 (S. cerevisiae) homolog B; SEC24 family, member B (S. cerevisiae); SEC24 homolog B, COPII coat complex component; SEC24 related gene family, member B; SEC24-related protein B; SEC24B; secretory protein 24
Gene Symbols: SEC24B
Molecular weight: 137,418 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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