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AGO4
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Belongs to the argonaute family. Ago subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation initiation |
| Chromosomal Location of human Ortholog: 1p34.3 |
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Cellular Component:
cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; nucleus; P-body; RISC complex; RISC-loading complex
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Molecular Function:
double-stranded RNA binding; miRNA binding; protein binding; RNA endonuclease activity; single-stranded RNA binding
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Biological Process:
male gonad development; male meiotic nuclear division; miRNA metabolic process; miRNA processing; miRNA-mediated gene silencing by inhibition of translation; miRNA-mediated gene silencing by mRNA destabilization; mRNA catabolic process; negative regulation of apoptotic process; pre-miRNA processing; regulation of cell morphogenesis; RISC complex assembly; RNA secondary structure unwinding; siRNA-mediated gene silencing by mRNA destabilization; synaptonemal complex assembly
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Reference #:
Q9HCK5
(UniProtKB)
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Alt. Names/Synonyms: AGO4; argonaute 4; argonaute 4, RISC catalytic component; Argonaute RISC catalytic component 4; argonaute RISC component 4; Argonaute4; eIF-2C 4; eIF2C 4; EIF2C4; Eukaryotic translation initiation factor 2C 4; eukaryotic translation initiation factor 2C, 4; hAgo4; KIAA1567; Protein argonaute-4
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Gene Symbols: AGO4
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Molecular weight:
97,097 Da
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Basal Isoelectric point:
9.21
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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