NDUFS4 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFS4 subunit family. Note: This description may include information from UniProtKB.
Protein type: EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 5q11.2
Cellular Component:  mitochondrial inner membrane; mitochondrial respiratory chain complex I; mitochondrion
Molecular Function:  NADH dehydrogenase (ubiquinone) activity; protein binding
Biological Process:  aerobic respiration; brain development; cellular respiration; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; positive regulation of fibroblast proliferation; proton motive force-driven mitochondrial ATP synthesis; reactive oxygen species metabolic process; regulation of protein phosphorylation; response to cAMP
Disease: Mitochondrial Complex I Deficiency
Reference #:  O43181 (UniProtKB)
Alt. Names/Synonyms: AQDQ; CI-18; CI-18 kDa; CI-AQDQ; complex I 18kDa subunit; Complex I-18 kDa; Complex I-AQDQ; MC1DN1; mitochondrial respiratory chain complex I (18-KD subunit); NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) iron-sulfur protein 4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH-coenzyme Q reductase, 18-KD; NADH-ubiquinone oxidoreductase 18 kDa subunit; NADH:ubiquinone oxidoreductase subunit S4; NDUFS4; NDUS4
Gene Symbols: NDUFS4
Molecular weight: 20,108 Da
Basal Isoelectric point: 10.3  Predict pI for various phosphorylation states
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NDUFS4

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein