TDO2 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Belongs to the tryptophan 2,3-dioxygenase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.11; Oxidoreductase
Chromosomal Location of human Ortholog: 4q32.1
Cellular Component:  cytosol
Molecular Function:  amino acid binding; heme binding; identical protein binding; metal ion binding; oxygen binding; protein binding; tryptophan 2,3-dioxygenase activity
Biological Process:  oxidation-reduction process; protein homotetramerization; response to nitroglycerin; tryptophan catabolic process; tryptophan catabolic process to kynurenine
Disease: Hypertryptophanemia
Reference #:  P48775 (UniProtKB)
Alt. Names/Synonyms: HYPTRP; T23O; TDO; TDO2; TO; TPH2; TRPO; Tryptamin 2,3-dioxygenase; Tryptophan 2,3-dioxygenase; Tryptophan oxygenase; Tryptophan pyrrolase; Tryptophanase
Gene Symbols: TDO2
Molecular weight: 47,872 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
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TDO2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene