ITK an intracellular tyrosine kinase of the Tec family expressed in T-cells. Plays an essential role in regulation of the adaptive immune response. Contains both SH2 and SH3 domains and plays a role in T-cell proliferation and differentiation. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Is recruited to the cell membrane following activation of the T-cell receptor (TCR). It is phosphorylated by LCK, followed by autophosphorylation leading to its full activation. Phosphorylates PLCG1. Itk-deficient murine T cells display defects in TCR/CD3-induced actin polymerization. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family
Chromosomal Location of Human Ortholog: 11 B1.1|11 27.75 cM
Cellular Component:  cell-cell junction; cytoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  activation of phospholipase C activity; adaptive immune response; B cell receptor signaling pathway; cytokine production; immune system process; interferon-gamma production; interleukin-4 production; intracellular signal transduction; NK T cell differentiation; peptidyl-tyrosine autophosphorylation; phosphorylation; protein phosphorylation; T cell receptor signaling pathway
Reference #:  Q03526 (UniProtKB)
Alt. Names/Synonyms: Emt; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; interleukin-2-inducible T cell kinase; Itk; Kinase EMT; Kinase TLK; OTTMUSP00000005641; T-cell-specific kinase; Tcsk; Tlk; Tsk; Tyrosine-protein kinase ITK/TSK
Gene Symbols: Itk
Molecular weight: 72,292 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene