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ITK
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3. Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. T-cell lines and natural killer cell lines. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family |
| Chromosomal Location of Human Ortholog: 11 B1.1|11 27.75 cM |
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Cellular Component:
cell-cell junction; cytoplasm; nucleus
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Molecular Function:
ATP binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity
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Biological Process:
activation of phospholipase C activity; adaptive immune response; B cell receptor signaling pathway; cytokine production; immune system process; interferon-gamma production; interleukin-4 production; intracellular signal transduction; NK T cell differentiation; peptidyl-tyrosine autophosphorylation; phosphorylation; protein phosphorylation; T cell receptor signaling pathway
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Reference #:
Q03526
(UniProtKB)
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Alt. Names/Synonyms: Emt; IL-2-inducible T-cell kinase; IL2 inducible T cell kinase; IL2-inducible T-cell kinase; interleukin-2-inducible T cell kinase; Itk; Kinase EMT; Kinase TLK; OTTMUSP00000005641; T-cell-specific kinase; Tcs; Tcsk; Tlk; Tsk; Tyrosine-protein kinase ITK/TSK
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Gene Symbols: Itk
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Molecular weight:
72,292 Da
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Basal Isoelectric point:
6.75
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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