C1QTNF4 May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent. Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection. Widely expressed at low levels (PubMed:21658842). Highest levels in adipocyte tissue and brain (PubMed:24366864). Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component:  extracellular space
Molecular Function:  cytokine activity
Biological Process:  positive regulation of interleukin-6 production; positive regulation of interleukin-6 secretion; positive regulation of interleukin-6-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; positive regulation of tumor necrosis factor secretion; regulation of signaling receptor activity
Reference #:  Q9BXJ3 (UniProtKB)
Alt. Names/Synonyms: C1q and TNF related 4; C1q and tumor necrosis factor related protein 4; C1q/TNF-related protein 4; C1QT4; C1QTNF4; Complement C1q tumor necrosis factor-related protein 4; complement-c1q tumor necrosis factor-related protein 4; CTRP4; ZACRP4
Gene Symbols: C1QTNF4
Molecular weight: 35,256 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene