JMJD2A Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. Belongs to the JHDM3 histone demethylase family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1p34.2-p34.1
Cellular Component:  cytosol; fibrillar center; nucleoplasm; nucleus
Molecular Function:  histone demethylase activity (H3-K36 specific); histone demethylase activity (H3-K9 specific); methylated histone binding; protein binding; ubiquitin protein ligase binding; zinc ion binding
Biological Process:  histone demethylation; histone H3-K36 demethylation; histone H3-K9 demethylation; negative regulation of autophagy; negative regulation of gene expression; negative regulation of transcription, DNA-templated; oxidation-reduction process; viral process
Reference #:  O75164 (UniProtKB)
Alt. Names/Synonyms: JHDM3A; JmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; Jumonji domain-containing protein 2A; KDM4A; KIAA0677; lysine (K)-specific demethylase 4A; Lysine-specific demethylase 4A
Gene Symbols: KDM4A
Molecular weight: 120,662 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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JMJD2A

Protein Structure Not Found.


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