MFHAS1 Probable GTP-binding protein. Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways. Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor. Both inhibits and activates the TLR2-dependent signaling pathway. Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype. It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway. Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway. Ubiquitously expressed. Overexpressed in malignant fibrous histiocytomas (PubMed:9973190). Expressed in red blood cells (at protein level) (PubMed:23327923). Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component:  cytoplasm
Molecular Function:  GTP binding; protein binding; protein phosphatase 2A binding; ubiquitin protein ligase binding
Biological Process:  erythrocyte differentiation; inflammatory response; innate immune response; negative regulation of inflammatory response; negative regulation of protein dephosphorylation; negative regulation of protein localization to nucleus; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of JNK cascade; positive regulation of p38MAPK cascade; positive regulation of protein kinase B signaling; positive regulation of toll-like receptor 2 signaling pathway; regulation of macrophage activation
Reference #:  Q9Y4C4 (UniProtKB)
Alt. Names/Synonyms: FLJ23354; leucine rich repeat containing 65; LRRC65; malignant fibrous histiocytoma amplified sequence 1; Malignant fibrous histiocytoma-amplified sequence 1; Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1; MASL1; MFH-amplified sequences with leucine-rich tandem repeats 1; MFHA1; MFHAS1
Gene Symbols: MFHAS1
Molecular weight: 116,950 Da
Basal Isoelectric point: 8.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB