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MFHAS1
Probable GTP-binding protein. Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways. Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor. Both inhibits and activates the TLR2-dependent signaling pathway. Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype. It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway. Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway. Ubiquitously expressed. Overexpressed in malignant fibrous histiocytomas (PubMed:9973190). Expressed in red blood cells (at protein level) (PubMed:23327923). Note: This description may include information from UniProtKB.
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| Protein type: Tumor suppressor |
| Chromosomal Location of human Ortholog: 8p23.1 |
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Cellular Component:
cytoplasm; cytoskeleton; lysosome; mitochondrion
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Molecular Function:
GTP binding; protein binding; protein phosphatase 2A binding; ubiquitin protein ligase binding
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Biological Process:
erythrocyte differentiation; inflammatory response; innate immune response; negative regulation of inflammatory response; negative regulation of protein dephosphorylation; negative regulation of protein localization to nucleus; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of JNK cascade; positive regulation of p38MAPK cascade; positive regulation of protein kinase B signaling; positive regulation of toll-like receptor 2 signaling pathway; regulation of macrophage activation; regulation of toll-like receptor signaling pathway; signal transduction
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Reference #:
Q9Y4C4
(UniProtKB)
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Alt. Names/Synonyms: FLJ23354; leucine rich repeat containing 65; LRRC65; malignant fibrous histiocytoma amplified sequence 1; Malignant fibrous histiocytoma-amplified sequence 1; Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1; malignant fibrous histiocytoma-amplified sequences with leucine-rich tandem repeats 1; MASL1; MFH-amplified sequences with leucine-rich tandem repeats 1; MFHA1; MFHAS1; ROCO4
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Gene Symbols: MFHAS1
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Molecular weight:
116,950 Da
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Basal Isoelectric point:
8.02
Predict pI for various phosphorylation states
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