TEC Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family
Chromosomal Location of mouse Ortholog: 5 C3.2|5 38.44 cM
Cellular Component:  cell-cell junction; cytoplasm; cytoskeleton; membrane; plasma membrane
Molecular Function:  ATP binding; kinase activity; lipid binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  adaptive immune response; B cell receptor signaling pathway; immune system process; integrin-mediated signaling pathway; intracellular signal transduction; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; protein phosphorylation; regulation of platelet activation; T cell receptor signaling pathway; tissue regeneration
Reference #:  P24604 (UniProtKB)
Alt. Names/Synonyms: cytoplasmic tyrosine kinase, Dscr28C related; protein tyrosine kinase TecI; protein tyrosine kinase TecIIA; protein tyrosine kinase TecIIB; protein tyrosine kinase TecIII; protein tyrosine kinase TecIV; Tec; tec protein tyrosine kinase; Tyrosine-protein kinase Tec
Gene Symbols: Tec
Molecular weight: 73,426 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TEC

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene