TBP
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Belongs to the TBP family. Widely expressed, with levels highest in the testis and ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription initiation complex |
Chromosomal Location of human Ortholog: 6q27 |
Cellular Component:
chromatin; cytoplasm; euchromatin; female germ cell nucleus; female pronucleus; male germ cell nucleus; male pronucleus; nucleoplasm; nucleus; protein-containing complex; RNA polymerase transcription factor SL1 complex; transcription factor TFIIA complex; transcription factor TFIID complex
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Molecular Function:
aryl hydrocarbon receptor binding; core promoter sequence-specific DNA binding; DNA-binding transcription factor binding; enzyme binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II general transcription initiation factor activity; RNA polymerase II general transcription initiation factor binding; RNA polymerase III general transcription initiation factor activity; TFIIB-class transcription factor binding; transcription cis-regulatory region binding
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Biological Process:
DNA-templated transcription initiation; mRNA transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; protein phosphorylation; RNA polymerase II preinitiation complex assembly; spermatogenesis; transcription by RNA polymerase II; transcription by RNA polymerase III; transcription initiation at RNA polymerase II promoter
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Disease: Parkinson Disease, Late-onset; Spinocerebellar Ataxia 17
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Reference #:
P20226
(UniProtKB)
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Alt. Names/Synonyms: GTF2D; GTF2D1; HDL4; MGC117320; MGC126054; MGC126055; SCA17; TATA box binding protein; TATA sequence-binding protein; TATA-binding factor; TATA-box binding protein; TATA-box binding protein N-terminal domain; TATA-box factor; TATA-box-binding protein; TBP; TF2D; TFIID; Transcription initiation factor TFIID TBP subunit
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Gene Symbols: TBP
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Molecular weight:
37,698 Da
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Basal Isoelectric point:
9.8
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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