TBP General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Belongs to the TBP family. Widely expressed, with levels highest in the testis and ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription initiation complex
Chromosomal Location of Human Ortholog: 6q27
Cellular Component:  cytoplasm; female pronucleus; male pronucleus; nuclear chromatin; nuclear euchromatin; nucleoplasm; nucleus; protein-containing complex; transcription factor TFIIA complex; transcription factor TFIID complex; transcriptional preinitiation complex
Molecular Function:  aryl hydrocarbon receptor binding; core promoter binding; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; protein binding; proximal promoter sequence-specific DNA binding; repressing transcription factor binding; RNA polymerase II general transcription initiation factor activity; RNA polymerase II repressing transcription factor binding; RNA polymerase III general transcription initiation factor activity; TFIIB-class transcription factor binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process:  positive regulation of gene expression, epigenetic; positive regulation of transcription, DNA-templated; regulation of signal transduction by p53 class mediator; regulation of transcription by RNA polymerase II; RNA polymerase II preinitiation complex assembly; snRNA transcription by RNA polymerase II; spermatogenesis; termination of RNA polymerase I transcription; transcription by RNA polymerase II; transcription by RNA polymerase III; transcription elongation from RNA polymerase I promoter; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter; viral process
Disease: Parkinson Disease, Late-onset; Spinocerebellar Ataxia 17
Reference #:  P20226 (UniProtKB)
Alt. Names/Synonyms: GTF2D; GTF2D1; MGC117320; MGC126054; MGC126055; SCA17; TATA box binding protein; TATA sequence-binding protein; TATA-binding factor; TATA-box binding protein N-terminal domain; TATA-box factor; TATA-box-binding protein; TBP; TF2D; TFIID; Transcription initiation factor TFIID TBP subunit
Gene Symbols: TBP
Molecular weight: 37,698 Da
Basal Isoelectric point: 9.8  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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