G-beta 1 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the WD repeat G protein beta family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric beta
Chromosomal Location of Human Ortholog: 4 E2|4 86.17 cM
Cellular Component:  cell body; dendrite; heterotrimeric G-protein complex; myelin sheath; photoreceptor inner segment; photoreceptor outer segment
Molecular Function:  alkylglycerophosphoethanolamine phosphodiesterase activity; G-protein coupled receptor binding; GTPase activity; GTPase binding; spectrin binding; type 1 angiotensin receptor binding
Biological Process:  cardiac muscle cell apoptotic process; cell proliferation; cellular response to hypoxia; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; phospholipase C-activating G-protein coupled receptor signaling pathway; phototransduction, visible light; retina development in camera-type eye; sensory perception of taste; signal transduction
Reference #:  P62874 (UniProtKB)
Alt. Names/Synonyms: AA409223; C77571; GBB1; Gnb-1; Gnb1; guanine nucleotide binding protein (G protein), beta 1; guanine nucleotide binding protein, beta 1; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; MGC98074; OTTMUSP00000011446; Transducin beta chain 1
Gene Symbols: Gnb1
Molecular weight: 37,377 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
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G-beta 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene