G-beta 1 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Belongs to the WD repeat G protein beta family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric beta
Chromosomal Location of human Ortholog: 1p36.33
Cellular Component:  cell body; cytosol; dendrite; heterotrimeric G-protein complex; membrane; photoreceptor disc membrane; photoreceptor inner segment; photoreceptor outer segment membrane; plasma membrane
Molecular Function:  alkylglycerophosphoethanolamine phosphodiesterase activity; GTPase activity; GTPase binding; protein binding; protein-containing complex binding; spectrin binding
Biological Process:  adenylate cyclase-activating dopamine receptor signaling pathway; cardiac muscle cell apoptotic process; cell proliferation; cellular response to catecholamine stimulus; cellular response to hypoxia; cellular response to prostaglandin E stimulus; G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; platelet activation; positive regulation of cytosolic calcium ion concentration; protein folding; protein heterotrimerization; Ras protein signal transduction; retina development in camera-type eye; rhodopsin mediated signaling pathway; sensory perception of taste; signal transduction; Wnt signaling pathway, calcium modulating pathway
Disease: Leukemia, Acute Lymphoblastic; Mental Retardation, Autosomal Dominant 42; Myelodysplastic Syndrome
Reference #:  P62873 (UniProtKB)
Alt. Names/Synonyms: beta subunit, signal-transducing proteins GS/GI; G protein subunit beta 1; G protein, beta-1 subunit; G-beta 1; GBB1; GNB1; guanine nucleotide binding protein (G protein), beta polypeptide 1; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; MRD42; testicular tissue protein Li 72; Transducin beta chain 1
Gene Symbols: GNB1
Molecular weight: 37,377 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
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G-beta 1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene