TRPC4 Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3 C|3 25.43 cM
Cellular Component:  basolateral plasma membrane; calcium channel complex; cation channel complex; caveola; cell surface; cortical cytoskeleton; cytoplasm; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; plasma membrane; protein-containing complex
Molecular Function:  beta-catenin binding; cadherin binding; calcium channel activity; inositol 1,4,5 trisphosphate binding; ion channel activity; protein binding; store-operated calcium channel activity
Biological Process:  calcium ion import; calcium ion transmembrane transport; calcium ion transport; gamma-aminobutyric acid secretion; ion transport; manganese ion transport; oligodendrocyte differentiation; regulation of calcium ion transport; regulation of cytosolic calcium ion concentration; transmembrane transport
Reference #:  Q9QUQ5 (UniProtKB)
Alt. Names/Synonyms: Capacitative calcium entry channel Trp4; CCE1; putative capacitative calcium entry channel; Receptor-activated cation channel TRP4; Short transient receptor potential channel 4; STRPC4; transient receptor potential cation channel, subfamily C, member 4; transient receptor protein 4; Trp4; TrpC4; Trrp4
Gene Symbols: Trpc4
Molecular weight: 111,575 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene