TRPC4 Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q13.3
Cellular Component:  basolateral plasma membrane; calcium channel complex; caveola; cell surface; cortical cytoskeleton; plasma membrane
Molecular Function:  beta-catenin binding; cadherin binding; protein binding; store-operated calcium channel activity
Biological Process:  calcium ion import; calcium ion transmembrane transport; calcium ion transport; gamma-aminobutyric acid secretion; oligodendrocyte differentiation
Reference #:  Q9UBN4 (UniProtKB)
Alt. Names/Synonyms: hTrp-4; hTrp4; MGC119570; MGC119571; MGC119572; MGC119573; Short transient receptor potential channel 4; transient receptor potential 4; transient receptor potential cation channel subfamily C member 4; transient receptor potential cation channel, subfamily C, member 4; Trp-related protein 4; TRP4; TRPC4
Gene Symbols: TRPC4
Molecular weight: 112,101 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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