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TEC
Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family |
| Chromosomal Location of human Ortholog: 4p12-p11 |
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Cellular Component:
cytoskeleton; cytosol; plasma membrane
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Molecular Function:
ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; phospholipid binding; protein binding; protein self-association
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Biological Process:
adaptive immune response; B cell receptor signaling pathway; integrin-mediated signaling pathway; intracellular signal transduction; protein phosphorylation; regulation of platelet activation; T cell receptor signaling pathway; tissue regeneration
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Reference #:
P42680
(UniProtKB)
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Alt. Names/Synonyms: MGC126760; MGC126762; PSCTK4; TEC; tec protein tyrosine kinase; Tyrosine-protein kinase Tec
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Gene Symbols: TEC
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Molecular weight:
73,581 Da
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Basal Isoelectric point:
8.69
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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