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SHANK2 iso4
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. Belongs to the SHANK family. Isoform 3 is present in epithelial colonic cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 11q13.3-q13.4 |
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Cellular Component:
apical plasma membrane; brush border membrane; ciliary membrane; cytosol; dendritic spine; glutamatergic synapse; growth cone; hippocampal mossy fiber to CA3 synapse; neurofilament; neuron projection; neuronal cell body; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone
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Molecular Function:
ionotropic glutamate receptor binding; protein binding; SH3 domain binding; structural constituent of postsynaptic density; synaptic receptor adaptor activity
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Biological Process:
adult behavior; adult locomotory behavior; associative learning; learning; long-term synaptic depression; long-term synaptic potentiation; maintenance of postsynaptic density structure; negative regulation of hippo signaling; positive regulation of cell population proliferation; regulation of postsynapse organization; response to nutrient; response to xenobiotic stimulus; social behavior; synapse assembly; vocalization behavior
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Disease: Autism, Susceptibility To, 17
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Reference #:
Q9UPX8-4
(UniProtKB)
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Alt. Names/Synonyms: AUTS17; cortactin SH3 domain-binding protein; Cortactin-binding protein 1; CORTBP1; CTTNBP1; GKAP/SAPAP interacting protein; KIAA1022; proline-rich synapse associated protein 1; Proline-rich synapse-associated protein 1; PROSAP1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains protein 2; SHAN2; SHANK; SHANK2; SHANK2 iso4; SPANK-3
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Gene Symbols: SHANK2
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Molecular weight:
134,931 Da
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Basal Isoelectric point:
5.45
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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