SHANK2 iso4 Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. Belongs to the SHANK family. Isoform 3 is present in epithelial colonic cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q13.3-q13.4
Cellular Component:  apical plasma membrane; brush border membrane; cell junction; ciliary membrane; cytosol; dendritic spine; growth cone; neuron projection; neuronal cell body; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; postsynaptic density
Molecular Function:  GKAP/Homer scaffold activity; ionotropic glutamate receptor binding; protein binding; SH3 domain binding
Biological Process:  adult behavior; learning; long-term synaptic depression; long-term synaptic potentiation; social behavior; synapse assembly; vocalization behavior
Disease: Autism, Susceptibility To, 17
Reference #:  Q9UPX8-4 (UniProtKB)
Alt. Names/Synonyms: cortactin SH3 domain-binding protein; Cortactin-binding protein 1; CORTBP1; CTTNBP1; GKAP/SAPAP interacting protein; KIAA1022; proline-rich synapse associated protein 1; Proline-rich synapse-associated protein 1; PROSAP1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains protein 2; SHAN2; SHANK; SHANK2; SHANK2 iso4; SPANK-3
Gene Symbols: SHANK2
Molecular weight: 134,931 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Select Structure to View Below

SHANK2 iso4

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene