APXL May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution. Belongs to the shroom family. Abundant in retina and melanoma; also in brain, placenta, lung, kidney and pancreas. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium
Chromosomal Location of human Ortholog: Xp22.2
Cellular Component:  adherens junction; apical junction complex; apical plasma membrane; bicellular tight junction; cortical actin cytoskeleton; cytoskeleton; microtubule; plasma membrane
Molecular Function:  actin binding; actin filament binding; beta-catenin binding; ligand-gated sodium channel activity; protein binding
Biological Process:  actin filament bundle assembly; actin filament organization; apical protein localization; brain development; camera-type eye development; camera-type eye morphogenesis; cell migration; cell morphogenesis; cellular pigment accumulation; ear development; establishment of melanosome localization; eye pigment granule organization; lens morphogenesis in camera-type eye; melanosome organization; sodium ion transmembrane transport
Reference #:  Q13796 (UniProtKB)
Alt. Names/Synonyms: apical protein, Xenopus laevis-like; Apical-like protein; APX homolog of Xenopus; APXL; DKFZp781J074; FLJ39277; HSAPXL; Protein APXL; Protein Shroom2; SHRM2; shroom family member 2; SHROOM2
Gene Symbols: SHROOM2
Molecular weight: 176,410 Da
Basal Isoelectric point: 6.64  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein