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H2BFS
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. Belongs to the histone H2B family. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of human Ortholog: 21q22.3 |
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Cellular Component:
cytosol; extracellular space; nucleoplasm; nucleosome; nucleus
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Molecular Function:
DNA binding; protein heterodimerization activity; structural constituent of chromatin
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Biological Process:
antibacterial humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; innate immune response in mucosa
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Reference #:
P57053
(UniProtKB)
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Alt. Names/Synonyms: H2B clustered histone 12 like; H2B histone family member S; H2B histone family, member S; H2B.S histone 1; H2B/s; H2BFS; H2BS1; Histone H2B type F-S; Histone H2B.s; histone protein
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Gene Symbols: H2BC12L
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Molecular weight:
13,813 Da
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Basal Isoelectric point:
10.37
Predict pI for various phosphorylation states
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