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SIPA1L3
Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Ras |
| Chromosomal Location of human Ortholog: 19q13.13-q13.2 |
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Cellular Component:
apical part of cell; apical plasma membrane; cytoplasm; Golgi apparatus; nucleoplasm; plasma membrane; stress fiber; tricellular tight junction
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Molecular Function:
GTPase activator activity; protein binding
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Biological Process:
activation of GTPase activity; cytoskeleton organization; epithelial cell morphogenesis; establishment of epithelial cell polarity; eye development; hematopoietic progenitor cell differentiation; regulation of small GTPase mediated signal transduction
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Disease: Cataract 45
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Reference #:
O60292
(UniProtKB)
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Alt. Names/Synonyms: CTRCT45; KIAA0545; SI1L3; signal induced proliferation associated 1 like 3; signal-induced proliferation-associated 1 like 3; Signal-induced proliferation-associated 1-like protein 3; SIPA1-like protein 3; SIPA1L3; SPA-1-like 3; SPA-1-like protein 3; SPAL3; SPAR3; spine-associated RapGAP 3
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Gene Symbols: SIPA1L3
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Molecular weight:
194,610 Da
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Basal Isoelectric point:
8.57
Predict pI for various phosphorylation states
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