Etk Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family
Chromosomal Location of Human Ortholog: Xp22.2
Cellular Component:  cytosol; nucleoplasm; plasma membrane; ruffle membrane
Molecular Function:  ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein tyrosine kinase activity
Biological Process:  apoptotic process; cell adhesion; intracellular signal transduction; mesoderm development; phosphatidylinositol biosynthetic process; protein autophosphorylation; protein phosphorylation; signal transduction
Reference #:  P51813 (UniProtKB)
Alt. Names/Synonyms: BMX; BMX non-receptor tyrosine kinase; Bone marrow tyrosine kinase gene in chromosome X protein; BTK-like on X chromosome; Cytoplasmic tyrosine-protein kinase BMX; Epithelial and endothelial tyrosine kinase; ETK; Etk/Bmx cytosolic tyrosine kinase; NTK38; NTK38 tyrosine kinase; PSCTK2; PSCTK3
Gene Symbols: BMX
Molecular weight: 78,011 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Etk

Protein Structure Not Found.


Substrate Sequence Logo
Open Substrate Page

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein