K17 a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 11 D|11 63.44 cM
Cellular Component:  cell periphery; cytoplasm; intermediate filament; intermediate filament cytoskeleton
Molecular Function:  MHC class II protein binding; MHC class II receptor activity; protein binding; structural molecule activity
Biological Process:  hair follicle morphogenesis; intermediate filament organization; keratinization; morphogenesis of an epithelium; positive regulation of cell growth; positive regulation of hair follicle development; positive regulation of translation; signal transduction
Reference #:  Q9QWL7 (UniProtKB)
Alt. Names/Synonyms: CK-17; Cytokeratin-17; K17; K1C17; keratin 17; keratin complex 1, acidic, gene 17; Keratin, type I cytoskeletal 17; Keratin-17; Krt1-17; Krt17; OTTMUSP00000002397
Gene Symbols: Krt17
Molecular weight: 48,162 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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K17

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene