K17 Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Belongs to the intermediate filament family. Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level). Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of human Ortholog: 17q21.2
Cellular Component:  cornified envelope; cytoskeleton; cytosol; intermediate filament cytoskeleton; keratin filament
Molecular Function:  protein binding; structural molecule activity
Biological Process:  epithelial cell differentiation; hair follicle morphogenesis; intermediate filament organization; keratinization; positive regulation of cell growth; positive regulation of hair follicle development; positive regulation of translation
Disease: Pachyonychia Congenita 2; Steatocystoma Multiplex
Reference #:  Q04695 (UniProtKB)
Alt. Names/Synonyms: 39.1; CK-17; Cytokeratin-17; K17; K1C17; keratin 17; keratin 17, type I; Keratin, type I cytoskeletal 17; Keratin-17; KRT17; PC; PC2; PCHC1
Gene Symbols: KRT17
Molecular weight: 48,106 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein