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H2B1D
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2B family. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of Human Ortholog: 13|13 A3.1 |
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Cellular Component:
chromosome; cytosol; nucleoplasm; nucleosome; nucleus
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Molecular Function:
DNA binding; protein heterodimerization activity
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Biological Process:
nucleosome assembly
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Reference #:
P10854
(UniProtKB)
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Alt. Names/Synonyms: H2B 291B; H2B clustered histone 14; H2b-291b; H2B1D; H2B1M; H2bc14; Hist1h2; Hist1h2bm; histone 1, H2bm; histone cluster 1, H2bm; Histone H2B type 1-M; OTTMUSP00000000458
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Gene Symbols: H2bc14
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Molecular weight:
13,936 Da
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Basal Isoelectric point:
10.31
Predict pI for various phosphorylation states
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