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DOCK4
Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. Belongs to the DOCK family. Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Ras; Motility/polarity/chemotaxis; Oncoprotein |
| Chromosomal Location of mouse Ortholog: 12 B1|12 18.06 cM |
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Cellular Component:
cytoplasm; cytosol; Golgi apparatus; membrane; nucleolus; plasma membrane; stereocilium; stereocilium bundle
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Molecular Function:
GTPase activator activity; guanyl-nucleotide exchange factor activity; PDZ domain binding; receptor tyrosine kinase binding; SH3 domain binding; small GTPase binding
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Biological Process:
cell chemotaxis; negative regulation of vascular associated smooth muscle contraction; positive regulation of vascular associated smooth muscle cell migration; small GTPase mediated signal transduction
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Reference #:
P59764
(UniProtKB)
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Alt. Names/Synonyms: 5330406C03; 6330411N01Rik; AF263288; C030023J22; dedicator of cytokinesis 4; Dedicator of cytokinesis protein 4; Dock4; Kiaa0716; mKIAA0716
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Gene Symbols: Dock4
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Molecular weight:
226,550 Da
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Basal Isoelectric point:
7.57
Predict pI for various phosphorylation states
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