DOCK4 Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. Belongs to the DOCK family. Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Ras; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 7q31.1
Cellular Component:  cytosol; Golgi apparatus; membrane; nucleolus; plasma membrane; stereocilium; stereocilium bundle
Molecular Function:  GTPase activator activity; guanyl-nucleotide exchange factor activity; PDZ domain binding; protein binding; Rac GTPase binding; receptor tyrosine kinase binding; SH3 domain binding
Biological Process:  cell chemotaxis; negative regulation of vascular smooth muscle contraction; positive regulation of GTPase activity; positive regulation of vascular associated smooth muscle cell migration; small GTPase mediated signal transduction
Reference #:  Q8N1I0 (UniProtKB)
Alt. Names/Synonyms: dedicator of cytokinesis 4; Dedicator of cytokinesis protein 4; DOCK4; FLJ34238; KIAA0716; MGC134911; MGC134912
Gene Symbols: DOCK4
Molecular weight: 225,206 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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