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calreticulin 3
During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Belongs to the calreticulin family. Testis specific. Note: This description may include information from UniProtKB.
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| Protein type: Cancer Testis Antigen (CTA); Chaperone |
| Chromosomal Location of mouse Ortholog: 8|8 B3.3 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; nuclear envelope
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Molecular Function:
calcium ion binding; protein binding; protein folding chaperone; unfolded protein binding
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Biological Process:
cell differentiation; protein folding; spermatogenesis; ubiquitin-dependent ERAD pathway
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Reference #:
Q9D9Q6
(UniProtKB)
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Alt. Names/Synonyms: 1700031L01Rik; 6330586I20Rik; Calr3; calreticulin 3; Calreticulin-2; Calreticulin-3; calspeculin; Calsperin; Crt; Crt2; cspn; CT93
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Gene Symbols: Calr3
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Molecular weight:
44,232 Da
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Basal Isoelectric point:
5.99
Predict pI for various phosphorylation states
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