SLC7A11 Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of mouse Ortholog: 3 C|3 21.72 cM
Cellular Component:  astrocyte projection; brush border membrane; cell surface; cytoskeleton; integral component of membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; rough endoplasmic reticulum
Molecular Function:  L-amino acid transmembrane transporter activity; transmembrane transporter activity
Biological Process:  adult behavior; amino acid transmembrane transport; amino acid transport; brain development; cellular response to oxidative stress; dipeptide import across plasma membrane; glutamate homeostasis; glutathione metabolic process; glutathione transmembrane transport; L-glutamate import across plasma membrane; limb development; lung alveolus development; modulation of chemical synaptic transmission; negative regulation of oxidative stress-induced neuron death; organic substance transport; platelet aggregation; regulation of AMPA glutamate receptor clustering; regulation of cell proliferation; regulation of cellular response to oxidative stress; regulation of cysteine metabolic process; regulation of glutamate metabolic process; regulation of glutathione biosynthetic process; regulation of melanin biosynthetic process; regulation of neutrophil apoptotic process; regulation of protein transport; regulation of synapse organization; response to organic cyclic compound; response to redox state; response to toxic substance; striatum development; transmembrane transport; ventricular system development; visual learning
Reference #:  Q9WTR6 (UniProtKB)
Alt. Names/Synonyms: 9930009M05Rik; AI451155; amino acid transport system xc cysteine/glutamate transporter; Amino acid transport system xc-; cysteine/glutamate transporter; Cystine/glutamate transporter; OTTMUSP00000023507; Slc7a11; sodium independent anionic amino acid transport system; solute carrier family 7 (cationic amino acid transporter, y+ system), member 11; Solute carrier family 7 member 11; sut; xCT
Gene Symbols: Slc7a11
Molecular weight: 55,456 Da
Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC7A11

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene