SLC7A11 Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of human Ortholog: 4q28.3
Cellular Component:  astrocyte projection; brush border membrane; cell surface; cytoskeleton; integral component of membrane; plasma membrane; rough endoplasmic reticulum
Molecular Function:  cystine:glutamate antiporter activity; protein binding
Biological Process:  adult behavior; amino acid transport; cellular response to oxidative stress; dipeptide import across plasma membrane; glutamate homeostasis; glutathione metabolic process; glutathione transmembrane transport; L-glutamate import across plasma membrane; lens fiber cell differentiation; leukocyte migration; limb development; lung alveolus development; modulation of chemical synaptic transmission; negative regulation of oxidative stress-induced neuron death; platelet aggregation; regulation of AMPA glutamate receptor clustering; regulation of cell proliferation; regulation of cysteine metabolic process; regulation of glutamate metabolic process; regulation of glutathione biosynthetic process; regulation of melanin biosynthetic process; regulation of neutrophil apoptotic process; regulation of protein transport; response to nicotine; response to organic cyclic compound; response to redox state; response to toxic substance; striatum development; ventricular system development; visual learning
Reference #:  Q9UPY5 (UniProtKB)
Alt. Names/Synonyms: amino acid transport system xc calcium channel blocker resistance protein CCBR1; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; CCBR1; Cystine/glutamate transporter; SLC7A11; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; Solute carrier family 7 member 11; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11; xCT
Gene Symbols: SLC7A11
Molecular weight: 55,423 Da
Basal Isoelectric point: 9.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC7A11

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene