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SLC7A11
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of human Ortholog: 4q28.3 |
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Cellular Component:
astrocyte projection; brush border membrane; cell surface; cytoskeleton; integral component of membrane; plasma membrane; rough endoplasmic reticulum
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Molecular Function:
cystine:glutamate antiporter activity; protein binding
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Biological Process:
adult behavior; amino acid transport; cellular response to oxidative stress; dipeptide import across plasma membrane; glutamate homeostasis; glutathione metabolic process; glutathione transmembrane transport; L-glutamate import across plasma membrane; lens fiber cell differentiation; leukocyte migration; limb development; lung alveolus development; modulation of chemical synaptic transmission; negative regulation of oxidative stress-induced neuron death; platelet aggregation; regulation of AMPA glutamate receptor clustering; regulation of cell proliferation; regulation of cysteine metabolic process; regulation of glutamate metabolic process; regulation of glutathione biosynthetic process; regulation of melanin biosynthetic process; regulation of neutrophil apoptotic process; regulation of protein transport; response to nicotine; response to organic cyclic compound; response to redox state; response to toxic substance; striatum development; ventricular system development; visual learning
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Reference #:
Q9UPY5
(UniProtKB)
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Alt. Names/Synonyms: amino acid transport system xc calcium channel blocker resistance protein CCBR1; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; CCBR1; Cystine/glutamate transporter; SLC7A11; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; Solute carrier family 7 member 11; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11; xCT
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Gene Symbols: SLC7A11
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Molecular weight:
55,423 Da
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Basal Isoelectric point:
9.29
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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