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SEC22B
SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. Belongs to the synaptobrevin family. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Vesicle |
| Chromosomal Location of human Ortholog: 1p12 |
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Cellular Component:
endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; ER to Golgi transport vesicle membrane; Golgi membrane; melanosome; phagocytic vesicle membrane; SNARE complex; transport vesicle
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Molecular Function:
protein binding; SNAP receptor activity
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Biological Process:
endoplasmic reticulum to Golgi vesicle-mediated transport; negative regulation of autophagosome assembly; positive regulation of protein catabolic process; protein transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; vesicle fusion with Golgi apparatus
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Reference #:
O75396
(UniProtKB)
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Alt. Names/Synonyms: ER-Golgi SNARE of 24 kDa; ERS-24; ERS24; SC22B; SEC22 homolog B, vesicle trafficking protein; SEC22 vesicle trafficking protein homolog B; SEC22 vesicle trafficking protein-like 1; SEC22 vesicle-trafficking protein homolog B; SEC22 vesicle-trafficking protein-like 1; SEC22B; SEC22L1; Vesicle-trafficking protein SEC22b
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Gene Symbols: SEC22B
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Molecular weight:
24,741 Da
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Basal Isoelectric point:
8.67
Predict pI for various phosphorylation states
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