SPRED2 Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 11|11 A3.1
Cellular Component:  cytoplasm; cytoplasmic vesicle; membrane; plasma membrane
Molecular Function:  protein binding; protein kinase binding; protein serine/threonine kinase inhibitor activity; stem cell factor receptor binding
Biological Process:  inactivation of MAPK activity; multicellular organism development; negative regulation of peptidyl-threonine phosphorylation; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of protein deacetylation; regulation of signal transduction
Reference #:  Q924S7 (UniProtKB)
Alt. Names/Synonyms: C79158; SPRE2; Spred-2; Spred2; sprouty protein with EVH-1 domain 2, related sequence; sprouty-related, EVH1 domain containing 2; Sprouty-related, EVH1 domain-containing protein 2
Gene Symbols: Spred2
Molecular weight: 46,794 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene