SPRED2 Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. Expressed in liver, skin, small intestine, salivary gland and prostate. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 2p14
Cellular Component:  cytosol; plasma membrane; transport vesicle membrane
Molecular Function:  protein binding; protein kinase binding; protein serine/threonine kinase inhibitor activity; stem cell factor receptor binding
Biological Process:  fibroblast growth factor receptor signaling pathway; inactivation of MAPK activity; multicellular organism development; negative regulation of peptidyl-threonine phosphorylation; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of protein deacetylation
Reference #:  Q7Z698 (UniProtKB)
Alt. Names/Synonyms: FLJ21897; FLJ31917; MGC163164; SPRE2; Spred-2; SPRED2; sprouty protein with EVH-1 domain 2, related sequence; sprouty related EVH1 domain containing 2; sprouty-related, EVH1 domain containing 2; Sprouty-related, EVH1 domain-containing protein 2
Gene Symbols: SPRED2
Molecular weight: 47,558 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
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Protein Structure Not Found.

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