MEKK2 Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family
Chromosomal Location of human Ortholog: 2q14.3
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  ATP binding; MAP kinase kinase kinase activity; metal ion binding; protein binding; protein kinase activity; protein kinase binding
Biological Process:  activation of JUN kinase activity; activation of MAPK activity; activation of MAPKK activity; cellular response to mechanical stimulus; positive regulation of transcription, DNA-templated; protein phosphorylation
Reference #:  Q9Y2U5 (UniProtKB)
Alt. Names/Synonyms: M3K2; MAP/ERK kinase kinase 2; MAP3K2; MAPK/ERK kinase kinase 2; MAPKKK2; MEK kinase 2; MEKK 2; MEKK2; MEKK2B; Mitogen-activated protein kinase kinase kinase 2
Gene Symbols: MAP3K2
Molecular weight: 69,741 Da
Basal Isoelectric point: 8.04  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene