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MEKK2
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.25; Kinase, protein; MEKK2 subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family |
| Chromosomal Location of human Ortholog: 2q14.3 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm
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Molecular Function:
ATP binding; MAP kinase kinase kinase activity; metal ion binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
cellular response to mechanical stimulus; intracellular signal transduction; MAPK cascade; protein phosphorylation
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Reference #:
Q9Y2U5
(UniProtKB)
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Alt. Names/Synonyms: M3K2; MAP/ERK kinase kinase 2; MAP3K2; MAPK/ERK kinase kinase 2; MAPKKK2; MEK kinase 2; MEKK 2; MEKK2; MEKK2B; Mitogen-activated protein kinase kinase kinase 2
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Gene Symbols: MAP3K2
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Molecular weight:
69,741 Da
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Basal Isoelectric point:
8.04
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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Regulation of P38 MAPKs
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SAPK/JNK Signaling Cascades
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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