SPRED1 Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Weakly expressed in embryonic cell line HEK293. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 2|2 E5
Cellular Component:  cytosol; membrane; nucleus; plasma membrane
Molecular Function:  phosphatase binding; protein binding; protein kinase binding; protein serine/threonine kinase inhibitor activity; stem cell factor receptor binding
Biological Process:  inactivation of MAPK activity; multicellular organism development; negative regulation of angiogenesis; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of ERK1 and ERK2 cascade; negative regulation of MAPK cascade; negative regulation of peptidyl-threonine phosphorylation; negative regulation of phosphatase activity; negative regulation of protein kinase activity; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of protein deacetylation; regulation of signal transduction; vasculogenesis involved in coronary vascular morphogenesis
Reference #:  Q924S8 (UniProtKB)
Alt. Names/Synonyms: 5730461F13Rik; AL024345; AW047647; OTTMUSP00000016218; SPRE1; Spred-1; Spred1; sprouty protein with EVH-1 domain 1, related sequence; sprouty-related protein 1 with EVH-1 domain; Sprouty-related, EVH1 domain-containing protein 1
Gene Symbols: Spred1
Molecular weight: 50,664 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Microtubule Dynamics
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SPRED1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene