SPRED1 Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Weakly expressed in embryonic cell line HEK293. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 15q14
Cellular Component:  caveola; cytosol; nucleus; plasma membrane
Molecular Function:  phosphatase binding; protein binding; protein kinase binding; protein serine/threonine kinase inhibitor activity; stem cell factor receptor binding
Biological Process:  fibroblast growth factor receptor signaling pathway; inactivation of MAPK activity; MAPK cascade; negative regulation of angiogenesis; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of ERK1 and ERK2 cascade; negative regulation of MAPK cascade; negative regulation of peptidyl-threonine phosphorylation; negative regulation of phosphatase activity; negative regulation of protein kinase activity; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of MAPK cascade; regulation of protein deacetylation; vasculogenesis involved in coronary vascular morphogenesis
Disease: Legius Syndrome
Reference #:  Q7Z699 (UniProtKB)
Alt. Names/Synonyms: EVH1/Sprouty domain containing protein; FLJ33903; hSpred1; NFLS; SPRE1; Spred-1; SPRED1; sprouty-related, EVH1 domain containing 1; Sprouty-related, EVH1 domain-containing protein 1; suppressor of Ras/MAPK activation
Gene Symbols: SPRED1
Molecular weight: 50,477 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB