GALNT2 an enzyme that catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. A single-pass type II membrane protein that localizes to the Golgi apparatus membrane. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 8|8 E2
Cellular Component:  Golgi apparatus; Golgi lumen; Golgi stack; perinuclear region of cytoplasm
Molecular Function:  manganese ion binding; polypeptide N-acetylgalactosaminyltransferase activity
Biological Process:  immunoglobulin biosynthetic process; O-glycan processing; protein O-linked glycosylation; protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine
Reference #:  Q6PB93 (UniProtKB)
Alt. Names/Synonyms: AI480629; GalNAc-T2; Galnt2; GALT2; OTTMUSP00000032094; Polypeptide GalNAc transferase 2; Polypeptide N-acetylgalactosaminyltransferase 2; Polypeptide N-acetylgalactosaminyltransferase 2 soluble form; pp-GaNTase 2; ppGaNTase-T2; Protein-UDP acetylgalactosaminyltransferase 2; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2
Gene Symbols: Galnt2
Molecular weight: 64,514 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
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GALNT2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene