GALNT2 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 1q42.13
Cellular Component:  endoplasmic reticulum membrane; extracellular region; Golgi apparatus; Golgi cisterna membrane; Golgi membrane; Golgi stack; integral component of Golgi membrane; perinuclear region of cytoplasm
Molecular Function:  carbohydrate binding; manganese ion binding; polypeptide N-acetylgalactosaminyltransferase activity; protein binding
Biological Process:  immunoglobulin biosynthetic process; O-glycan processing; protein O-linked glycosylation; protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine
Reference #:  Q10471 (UniProtKB)
Alt. Names/Synonyms: GalNAc-T2; GALNT2; GALT2; Polypeptide GalNAc transferase 2; Polypeptide N-acetylgalactosaminyltransferase 2; Polypeptide N-acetylgalactosaminyltransferase 2 soluble form; pp-GaNTase 2; Protein-UDP acetylgalactosaminyltransferase 2; UDP-GalNAc transferase 2; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
Gene Symbols: GALNT2
Molecular weight: 64,733 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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