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GALNT2
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase |
| Chromosomal Location of human Ortholog: 1q42.13 |
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Cellular Component:
endoplasmic reticulum membrane; extracellular region; Golgi apparatus; Golgi cisterna membrane; Golgi membrane; Golgi stack; perinuclear region of cytoplasm
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Molecular Function:
carbohydrate binding; manganese ion binding; polypeptide N-acetylgalactosaminyltransferase activity; protein binding
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Biological Process:
O-glycan processing; protein maturation; protein O-linked glycosylation; protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine
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Disease: Congenital Disorder Of Glycosylation, Type Iit
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Reference #:
Q10471
(UniProtKB)
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Alt. Names/Synonyms: CDG2T; GalNAc-T2; GALNT2; GALT2; Polypeptide GalNAc transferase 2; Polypeptide N-acetylgalactosaminyltransferase 2; Polypeptide N-acetylgalactosaminyltransferase 2 soluble form; pp-GaNTase 2; Protein-UDP acetylgalactosaminyltransferase 2; UDP-GalNAc transferase 2; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
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Gene Symbols: GALNT2
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Molecular weight:
64,733 Da
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Basal Isoelectric point:
8.63
Predict pI for various phosphorylation states
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