COPB2 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner. Belongs to the WD repeat COPB2 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 9|9 E3.3
Cellular Component:  COPI vesicle coat; cytoplasm; cytoplasmic vesicle; Golgi apparatus; Golgi membrane; membrane; membrane coat
Molecular Function:  protein kinase C binding; structural molecule activity
Biological Process:  ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; intracellular protein transport; protein transport; retrograde vesicle-mediated transport, Golgi to ER; toxin transport; vesicle-mediated transport
Reference #:  O55029 (UniProtKB)
Alt. Names/Synonyms: AI256832; Beta'-coat protein; Beta'-COP; coatomer protein complex, subunit beta 2 (beta prime); Coatomer subunit beta'; Copb2; p102
Gene Symbols: Copb2
Molecular weight: 102,449 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene