MEKK4 Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family
Chromosomal Location of Human Ortholog: 6q26
Cellular Component:  cytoplasm; perinuclear region of cytoplasm
Molecular Function:  ATP binding; MAP kinase kinase kinase activity; metal ion binding; protein binding
Biological Process:  activation of MAPKK activity; chorionic trophoblast cell differentiation; intracellular signal transduction; male germ-line sex determination; MAPK cascade; placenta development; positive regulation of JUN kinase activity; positive regulation of p38MAPK cascade; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; regulation of gene expression; response to UV-C
Reference #:  Q9Y6R4 (UniProtKB)
Alt. Names/Synonyms: dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4); FLJ42439; KIAA0213; M3K4; MAP three kinase 1; MAP/ERK kinase kinase 4; MAP3K4; MAPK/ERK kinase kinase 4; MAPKKK4; MEK kinase 4; MEKK 4; MEKK4; Mitogen-activated protein kinase kinase kinase 4; MTK1; predicted protein of HQ0412; PRO0412; SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of
Gene Symbols: MAP3K4
Molecular weight: 181,685 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
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MEKK4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein