H2B1N Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2B family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p22.1
Cellular Component:  cytosol; nucleoplasm; nucleosome; nucleus
Molecular Function:  DNA binding; protein heterodimerization activity
Biological Process:  nucleosome assembly; protein ubiquitination
Reference #:  Q99877 (UniProtKB)
Alt. Names/Synonyms: H2B histone family, member D; H2B/d; H2B1N; H2BFD; HIST1H2BN; HIST1H3I; histone 1, H2bn; histone cluster 1, H2bn; Histone H2B type 1-N; Histone H2B.d; MGC125414; MGC125415; MGC125416; MGC9388
Gene Symbols: HIST1H2BN
Molecular weight: 13,922 Da
Basal Isoelectric point: 10.31  Predict pI for various phosphorylation states
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H2B1N

Protein Structure Not Found.

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