H2B1C a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 13|13 A3.1
Cellular Component:  cytosol; extracellular space; nucleoplasm
Molecular Function:  DNA binding; identical protein binding
Biological Process:  antibacterial humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; innate immune response in mucosa; nucleosome assembly
Reference #:  Q6ZWY9 (UniProtKB)
Alt. Names/Synonyms: 2610022J01Rik; H2B histone family, member S; H2B1C; H2bfs; Hist1h2bc; Hist1h2be; Hist1h2bg; histone 1, H2bc; histone cluster 1, H2bc; Histone H2B type 1-C/E/G; OTTMUSP00000000534; R74621
Gene Symbols: Hist1h2bc
Molecular weight: 13,906 Da
Basal Isoelectric point: 10.31  Predict pI for various phosphorylation states
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H2B1C

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene