H2B1C Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. Belongs to the histone H2B family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: 6p22.2
Cellular Component:  cytosol; extracellular space; nucleoplasm; nucleosome
Molecular Function:  DNA binding; identical protein binding; protein binding; protein heterodimerization activity; structural constituent of chromatin
Biological Process:  antibacterial humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; innate immune response in mucosa; nucleosome assembly
Reference #:  P62807 (UniProtKB)
Alt. Names/Synonyms: dJ221C16.3; H2B clustered histone 4; H2B histone family, member L; H2B.1; H2B/a; H2B/g; H2B/h; H2B/k; H2B/l; H2B1C; H2BC10; H2BC4; H2BC6; H2BC7; H2BC8; H2BFA; H2BFG; H2BFH; H2BFK; H2BFL; HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI; histone 1, H2bc; histone cluster 1 H2B family member c; histone cluster 1, H2bc; Histone H2B type 1-C/E/F/G/I; Histone H2B.1 A; Histone H2B.a; Histone H2B.g; Histone H2B.h; Histone H2B.k; Histone H2B.l; MGC104246
Gene Symbols: H2BC4
Molecular weight: 13,775 Da
Basal Isoelectric point: 10.32  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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