SACS Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins. Highly expressed in the central nervous system. Also found in skeletal muscle and at low levels in pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chaperone
Chromosomal Location of Human Ortholog: 14 D1|14 32.13 cM
Cellular Component:  cytoplasm
Molecular Function:  low-density lipoprotein particle receptor binding
Reference #:  Q9JLC8 (UniProtKB)
Alt. Names/Synonyms: A230052M14; DnaJ homolog subfamily C member 29; DNAJC29; E130115J16Rik; Kiaa0730; mKIAA0730; Sacs; Sacsin
Gene Symbols: Sacs
Molecular weight: 520,685 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
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SACS

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene